Open Targets Genetics: systematic identification of trait-associated genes using large-scale genetics and functional genomics.

ABSTRACT: Open Targets Genetics (https://genetics.opentargets.org) is an open-access integrative resource that aggregates human GWAS and functional genomics data including gene expression, protein abundance, chromatin interaction and conformation data from a wide range of cell types and tissues to make robust connections between GWAS-associated loci, variants and likely causal genes. This enables systematic identification and prioritisation of likely causal variants and genes across all published trait-associated loci. In this paper, we describe the public resources we aggregate, the technology and analyses we use, and the functionality that the portal offers. Open Targets Genetics can be searched by variant, gene or study/phenotype. It offers tools that enable users to prioritise causal variants an

SUBMITTER: Ghoussaini M 

PROVIDER: S-EPMC7778936 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature