IndiGenomes: a comprehensive resource of genetic variants from over 1000 Indian genomes.

ABSTRACT: With the advent of next-generation sequencing, large-scale initiatives for mining whole genomes and exomes have been employed to better understand global or population-level genetic architecture. India encompasses more than 17% of the world population with extensive genetic diversity, but is under-represented in the global sequencing datasets. This gave us the impetus to perform and analyze the whole genome sequencing of 1029 healthy Indian individuals under the pilot phase of the 'IndiGen' program. We generated a compendium of 55,898,122 single allelic genetic variants from geographically distinct Indian genomes and calculated the allele frequency, allele count, allele number, along with the number of heterozygous or homozygous individuals. In the present study, these variants were system

SUBMITTER: Jain A 

PROVIDER: S-EPMC7778947 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature