RMDisease: a database of genetic variants that affect RNA modifications, with implications for epitranscriptome pathogenesis.

ABSTRACT: Deciphering the biological impacts of millions of single nucleotide variants remains a major challenge. Recent studies suggest that RNA modifications play versatile roles in essential biological mechanisms, and are closely related to the progression of various diseases including multiple cancers. To comprehensively unveil the association between disease-associated variants and their epitranscriptome disturbance, we built RMDisease, a database of genetic variants that can affect RNA modifications. By integrating the prediction results of 18 different RNA modification prediction tools and also 303,426 experimentally-validated RNA modification sites, RMDisease identified a total of 202,307 human SNPs that may affect (add or remove) sites of eight types of RNA modifications (m6A, m5C, m1A, m5U

SUBMITTER: Chen K 

PROVIDER: S-EPMC7778951 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature