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Insights into the origin and diversification of bovine viral diarrhea virus 1 subtypes.

ABSTRACT: In this study, we performed phylogenetic and evolutionary analysis on bovine viral diarrhea virus 1 (BVDV-1) sequences to investigate the origin and temporal diversification of different BVDV-1 subtypes. Dated phylogenies using the complete polyprotein sequence were reconstructed, and the time of the most recent common ancestor (tMRCA) was estimated. The results demonstrated that BVDV-1 subtypes clustered into two phylogenetic clades, where the predominant subtypes worldwide grouped together. In the temporal analysis, the tMRCA of BVDV-1 was 1336, and the diversification into different subtypes appears to have occurred around 363 years ago. The present results help to elucidate the origins of BVDV-1 subtypes and the dynamics of ruminant pestiviruses.

SUBMITTER: Weber MN

PROVIDER: S-EPMC7779086 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature

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Insights into the origin and diversification of bovine viral diarrhea virus 1 subtypes.

Weber Matheus N MN Wolf Jonas M JM da Silva Mariana S MS Mosena Ana Cristina S ACS Budaszewski Renata F RF Lunge Vagner R VR Canal Cláudio W CW

Archives of virology 20210103 2

In this study, we performed phylogenetic and evolutionary analysis on bovine viral diarrhea virus 1 (BVDV-1) sequences to investigate the origin and temporal diversification of different BVDV-1 subtypes. Dated phylogenies using the complete polyprotein sequence were reconstructed, and the time of the most recent common ancestor (tMRCA) was estimated. The results demonstrated that BVDV-1 subtypes clustered into two phylogenetic clades, where the predominant subtypes worldwide grouped together. In ...[more]

PMID: 33392819

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