Associations of human milk oligosaccharides and bioactive proteins with infant growth and development among Malawian mother-infant dyads.

ABSTRACT:

Background

Human milk oligosaccharides (HMOs) and bioactive breast milk proteins have many beneficial properties. Information is sparse regarding associations between these milk constituents and infant growth and development in lower-income countries.

Objectives

We aimed to examine associations of milk content of HMOs and bioactive proteins at 6 mo postpartum with infant growth and motor and cognitive development. These are secondary analyses of a randomized controlled trial in rural Malawi.

Methods

Breast milk samples were analyzed at 6 mo (n = 659) for general categories of HMOs (total HMOs, fucosylated HMOs, and sialylated HMOs), 51 individual HMOs, and 6 bioactive proteins (lactalbumin, lactoferrin, lysozyme, antitrypsin, IgA, and osteopontin). We examined associa

SUBMITTER: Jorgensen JM 

PROVIDER: S-EPMC7779225 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature