Revisiting the critical weight hypothesis for regulation of pubertal timing in boys.

ABSTRACT:

Background

Recent findings indicate that there is a body weight-sensing homeostatic regulation of body weight in postpubertal rodents and humans. It is possible that body weight sensing also might be involved in the regulation of pubertal timing. Although an early small study suggested that there is a critical body weight for pubertal timing in girls, most studies have focused on BMI and reported an inverse association between BMI and pubertal timing.

Objectives

In the present longitudinal well-powered cohort study, we revisited the critical weight hypothesis and tested if prepubertal body weight is a more robust inverse predictor of pubertal timing than prepubertal BMI in boys.

Method

We included men born during 1945-1961 (old cohort; n = 31,971) and men born during

SUBMITTER: Bygdell M 

PROVIDER: S-EPMC7779230 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature