Low-density lipoprotein cholesterol : high-density lipoprotein cholesterol ratio is associated with incident diabetes in Chinese adults: A retrospective cohort study.

ABSTRACT:

Aims/introduction

Dyslipidemia plays a critical role in the pathogenesis of metabolic syndrome and diabetes. Evidence has increasingly shown that the ratio of low- to high-density lipoprotein cholesterol (LDL-C/HDL-C) is a novel marker for increased risk of insulin resistance and cardiovascular diseases. However, the correlation between the LDL-C/HDL-C ratio and diabetes risk is rarely reported. This is the first study to investigate the association between the LDL-C/HDL-C ratio and new-onset diabetes in a large community-based cohort.

Materials and methods

In this retrospective cohort study, a total of 116,661 adults without baseline diabetes were enrolled. Participants were stratified into four groups based on LDL-C/HDL-C ratio quartiles. The outcome of interest was new-on

SUBMITTER: Wei L 

PROVIDER: S-EPMC7779276 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature