Glucosinolate induces transcriptomic and metabolic reprogramming in Helicoverpa armigera.

ABSTRACT: Glucosinolates protect plants from herbivory. Lepidopteran insects have developed resistance to glucosinolates which is well studied. However, the molecular effects of glucosinolate intake on insects are unexplored. To elucidate this, we performed transcriptomics and metabolomics of sinigrin-fed Helicoverpa armigera. Transcriptomics exhibits significant dysregulation of 2375 transcripts, of which 1575 are upregulated and 800 downregulated. Gene Ontology analysis of differentially expressed genes reveals that key hydrolases, oxidoreductases, and transferases are majorly affected. The negative impact of sinigrin is significant and localized in the endomembrane system and mitochondria. It also disturbs various biological processes such as regulation of protein metabolism and cytoskelet

SUBMITTER: Jagdale S 

PROVIDER: S-EPMC7779390 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature