Scattered slice SHARD reconstruction for motion correction in multi-shell diffusion MRI.

ABSTRACT: Diffusion MRI offers a unique probe into neural microstructure and connectivity in the developing brain. However, analysis of neonatal brain imaging data is complicated by inevitable subject motion, leading to a series of scattered slices that need to be aligned within and across diffusion-weighted contrasts. Here, we develop a reconstruction method for scattered slice multi-shell high angular resolution diffusion imaging (HARDI) data, jointly estimating an uncorrupted data representation and motion parameters at the slice or multiband excitation level. The reconstruction relies on data-driven representation of multi-shell HARDI data using a bespoke spherical harmonics and radial decomposition (SHARD), which avoids imposing model assumptions, thus facilitating to compare various microstruc

SUBMITTER: Christiaens D 

PROVIDER: S-EPMC7779423 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature