Longitudinal change in executive function is associated with impaired top-down frontolimbic regulation during reappraisal in older adults.

ABSTRACT: Networks in the prefrontal cortex (PFC) that are important for executive function are also engaged in adaptive responding to negative events. These networks are particularly vulnerable to age-related structural atrophy and an associated loss of executive function, yet existing evidence suggests preserved emotion processing ability in ageing. Using longitudinally acquired data from a battery of cognitive tasks, we defined a metric for the rate of decline of executive function. With this metric, we investigated relationships between changes in executive function and emotion reappraisal ability and brain structure, in 34 older adults, using functional and structural MRI. During task-based fMRI, participants were asked to cognitively reappraise negatively valenced images. We hypothesised one o

SUBMITTER: Lloyd WK 

PROVIDER: S-EPMC7779563 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature