Single-cell profiling of the human decidual immune microenvironment in patients with recurrent pregnancy loss.

ABSTRACT: Maintaining homeostasis of the decidual immune microenvironment at the maternal-fetal interface is essential for placentation and reproductive success. Although distinct decidual immune cell subpopulations have been identified under normal conditions, systematic understanding of the spectrum and heterogeneity of leukocytes under recurrent miscarriage in human deciduas remains unclear. To address this, we profiled the respective transcriptomes of 18,646 primary human decidual immune cells isolated from patients with recurrent pregnancy loss (RPL) and healthy controls at single-cell resolution. We discovered dramatic differential distributions of immune cell subsets in RPL patients compared with the normal decidual immune microenvironment. Furthermore, we found a subset of decidual natural k

SUBMITTER: Guo C 

PROVIDER: S-EPMC7779601 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature