Serial Molecular Profiling of Low-grade Prostate Cancer to Assess Tumor Upgrading: A Longitudinal Cohort Study.

ABSTRACT:

Background

The potential for low-grade (grade group 1 [GG1]) prostate cancer (PCa) to progress to high-grade disease remains unclear.

Objective

To interrogate the molecular and biological features of low-grade PCa serially over time.

Design, setting, and participants

Nested longitudinal cohort study in an academic active surveillance (AS) program. Men were on AS for GG1 PCa from 2012 to 2017.

Intervention

Electronic tracking and resampling of PCa using magnetic resonance imaging/ultrasound fusion biopsy.

Outcome measurements and statistical analysis

ERG immunohistochemistry (IHC) and targeted DNA/RNA next-generation sequencing were performed on initial and repeat biopsies. Tumor clonality was assessed. Molecular data were compared between men who upgrade

SUBMITTER: Salami SS 

PROVIDER: S-EPMC7779657 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature