Quantifying ADC bystander payload penetration with cellular resolution using pharmacodynamic mapping.

ABSTRACT: With the recent approval of 3 new antibody drug conjugates (ADCs) for solid tumors, this class of drugs is gaining momentum for the targeted treatment of cancer. Despite significant investment, there are still fundamental issues that are incompletely understood. Three of the recently approved ADCs contain payloads exhibiting bystander effects, where the payload can diffuse out of a targeted cell into adjacent cells. These effects are often studied using a mosaic of antigen positive and negative cells. However, the distance these payloads can diffuse in tumor tissue while maintaining a lethal concentration is unclear. Computational studies suggest bystander effects partially compensate for ADC heterogeneity in tumors in addition to targeting antigen negative cells. However, this type of stu

SUBMITTER: Khera E 

PROVIDER: S-EPMC7779838 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature