Differential glycosylation of collagen modulates lung cancer stem cell subsets through β1 integrin-mediated interactions.

ABSTRACT: In lung cancer, CD133+ cells represent the subset of cancer stem cells (CSC) able to sustain tumor growth and metastatic dissemination. CSC function is tightly regulated by specialized niches composed of both stromal cells and extracellular matrix (ECM) proteins, mainly represented by collagen. The relevance of collagen glycosylation, a fundamental post-translational modification controlling several biological processes, in regulating tumor cell phenotype remains, however, largely unexplored. To investigate the bioactive effects of differential ECM glycosylation on lung cancer cells, we prepared collagen films functionalized with glucose (Glc-collagen) and galactose (Gal-collagen) exploiting a neoglycosylation approach based on a reductive amination of maltose and lactose with the amino re

SUBMITTER: Gardelli C 

PROVIDER: S-EPMC7780011 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature