The blockade of interleukin-33 released by hepatectomy would be a promising treatment option for cholangiocarcinoma.

ABSTRACT: Interleukin-33 (IL-33), an alarmin released during tissue injury, facilitates the development of cholangiocarcinoma (CCA) in a murine model. However, it is unclear whether IL-33 is associated with human CCA. The aim of this study was to support the following hypothesis: IL-33 is released during hepatectomy for CCA, subsequently facilitating the development of subclinical CCA and eventually leading to recurrent disease. IL-33 expression was assessed in various samples from both humans and mice including resected liver and paired plasma samples collected at hepatectomy and after surgery, and its influences on recurrent disease and patient prognosis were determined. Homogenized human liver samples with high or low IL-33 expression were added to the culture medium of human CCA cells, and the c

SUBMITTER: Nagaoka S 

PROVIDER: S-EPMC7780022 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature