Reduction of inflammation in chronic pancreatitis using a soy bread intervention: A feasibility study.

ABSTRACT:

Introduction

Chronic pancreatitis is a chronic inflammatory disease, which progresses to fibrosis. Currently there are no interventions to delay or stop the progression to irreversible organ damage. In this study, we assessed the tolerability and feasibility of administering soy bread to reduce circulating inflammatory mediators.

Methods

Subjects with chronic pancreatitis diagnosed using the American Pancreatic Association diagnostic guidelines were enrolled. During the dose escalation (DE) phase, subjects received one week of soy bread based using a 3 + 3 dose-escalation design, which was then followed by a maximally tolerated dose (MTD) phase with four weeks of intervention. Dose-limiting toxicities (DLTs) were monitored. Plasma cytokine levels were measured using a Meso S

SUBMITTER: Ahn-Jarvis J 

PROVIDER: S-EPMC7780088 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature