Delivery of a mitochondria-targeted antioxidant from biocompatible, polymeric nanofibrous scaffolds.

ABSTRACT: Cardiovascular disease has been associated with increased levels of reactive oxygen species (ROS). Recently, we have shown that a critical balance between cytosolic ROS and mitochondrial ROS is crucial in cardiovascular health and that modulation of mitochondrial ROS helps prevent detrimental effects of cytosolic ROS on endothelial cells (EC) in transgenic animals. Here, we report the development of a controlled delivery system for a mitochondria-targeted antioxidant, JP4-039, from an electrospun scaffold made of FDA-approved biocompatible polymeric nanofibers. We demonstrate that the active antioxidant moiety was preserved in released JP4-039 for over 72 h using electron paramagnetic resonance. We also show that both the initial burst release of the drug within the first 20 min and the en

SUBMITTER: Hamedani Y 

PROVIDER: S-EPMC7780095 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature