Ontology highlight
ABSTRACT:
SUBMITTER: Focht D
PROVIDER: S-EPMC7780149 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Focht Dorota D Neumann Caroline C Lyons Joseph J Eguskiza Bilbao Ander A Blunck Rickard R Malinauskaite Lina L Schwarz Ilona O IO Javitch Jonathan A JA Quick Matthias M Nissen Poul P
The EMBO journal 20201106 1
MhsT of Bacillus halodurans is a transporter of hydrophobic amino acids and a homologue of the eukaryotic SLC6 family of Na<sup>+</sup> -dependent symporters for amino acids, neurotransmitters, osmolytes, or creatine. The broad range of transported amino acids by MhsT prompted the investigation of the substrate recognition mechanism. Here, we report six new substrate-bound structures of MhsT, which, in conjunction with functional studies, reveal how the flexibility of a Gly-Met-Gly (GMG) motif i ...[more]