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The Role of Chondroitin Sulfate Proteoglycans in Nervous System Development.

ABSTRACT: The orderly development of the nervous system is characterized by phases of cell proliferation and differentiation, neural migration, axonal outgrowth and synapse formation, and stabilization. Each of these processes is a result of the modulation of genetic programs by extracellular cues. In particular, chondroitin sulfate proteoglycans (CSPGs) have been found to be involved in almost every aspect of this well-orchestrated yet delicate process. The evidence of their involvement is complex, often contradictory, and lacking in mechanistic clarity; however, it remains obvious that CSPGs are key cogs in building a functional brain. This review focuses on current knowledge of the role of CSPGs in each of the major stages of neural development with emphasis on areas requiring further investigation.

SUBMITTER: Mencio CP

PROVIDER: S-EPMC7780190 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature

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The Role of Chondroitin Sulfate Proteoglycans in Nervous System Development.

Mencio Caitlin P CP Hussein Rowan K RK Yu Panpan P Geller Herbert M HM

The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 20200916 1

The orderly development of the nervous system is characterized by phases of cell proliferation and differentiation, neural migration, axonal outgrowth and synapse formation, and stabilization. Each of these processes is a result of the modulation of genetic programs by extracellular cues. In particular, chondroitin sulfate proteoglycans (CSPGs) have been found to be involved in almost every aspect of this well-orchestrated yet delicate process. The evidence of their involvement is complex, often ...[more]

PMID: 32936033

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