Early corticosteroids are associated with lower mortality in critically ill patients with COVID-19: a cohort study.

ABSTRACT:

Background

Critically ill patients with coronavirus disease 19 (COVID-19) have a high fatality rate likely due to a dysregulated immune response. Corticosteroids could attenuate this inappropriate response, although there are still some concerns regarding its use, timing, and dose.

Methods

This is a nationwide, prospective, multicenter, observational, cohort study in critically ill adult patients with COVID-19 admitted into Intensive Care Units (ICU) in Spain from 12th March to 29th June 2020. Using a multivariable Cox model with inverse probability weighting, we compared relevant outcomes between patients treated with early corticosteroids (before or within the first 48 h of ICU admission) with those who did not receive early corticosteroids (delayed group) or any corticost

SUBMITTER: Monedero P 

PROVIDER: S-EPMC7780210 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature