Choline kinase alpha impairment overcomes TRAIL resistance in ovarian cancer cells.

ABSTRACT:

Background

Choline kinase-α (ChoKα/CHKA) overexpression and hyper-activation sustain altered choline metabolism conferring the cholinic phenotype to epithelial ovarian cancer (OC), the most lethal gynecological tumor. We previously proved that CHKA down-modulation reduced OC cell aggressiveness and increased sensitivity to in vitro chemotherapeutics' treatment also affecting intracellular content of one-carbon metabolites. In tumor types other than ovary, methionine decrease was shown to increase sensitivity to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-receptor 2 triggering. These effects were suggestive of a potential role for ChoKα in regulating susceptibility to TRAIL cytokine.

Methods

The relationship between ChoKα/CHKA and TRAIL-receptor 2 (TRAIL-R

SUBMITTER: Rizzo A 

PROVIDER: S-EPMC7780408 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature