Conversion of Urine Protein-Creatinine Ratio or Urine Dipstick Protein to Urine Albumin-Creatinine Ratio for Use in Chronic Kidney Disease Screening and Prognosis : An Individual Participant-Based Meta-analysis.

ABSTRACT:

Background

Although measuring albuminuria is the preferred method for defining and staging chronic kidney disease (CKD), total urine protein or dipstick protein is often measured instead.

Objective

To develop equations for converting urine protein-creatinine ratio (PCR) and dipstick protein to urine albumin-creatinine ratio (ACR) and to test their diagnostic accuracy in CKD screening and staging.

Design

Individual participant-based meta-analysis.

Setting

12 research and 21 clinical cohorts.

Participants

919 383 adults with same-day measures of ACR and PCR or dipstick protein.

Measurements

Equations to convert urine PCR and dipstick protein to ACR were developed and tested for purposes of CKD screening (ACR ≥30 mg/g) and staging (stage A2: ACR of 3

SUBMITTER: Sumida K 

PROVIDER: S-EPMC7780415 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature