Glioblastoma surgery related emotion recognition deficits are associated with right cerebral hemisphere tract changes.

ABSTRACT: Patients with glioblastoma face abysmal overall survival, cognitive deficits, poor quality of life and limitations to social participation; partly attributable to surgery. Emotion recognition deficits mediated by pathophysiological mechanisms in the right inferior fronto-occipital fasciculus and right inferior longitudinal fasciculus have been demonstrated in traumatic brain injury and dementia, with negative associations for social participation. We hypothesize similar mechanisms occur in patients undergoing resection surgery for glioblastoma. Here, we apply tract-based spatial statistics using a combination of automated image registration methods alongside cognitive testing before and after surgery. In this prospective, longitudinal, observational study of 15 patients, surgery is associa

SUBMITTER: Sinha R 

PROVIDER: S-EPMC7780443 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature