Cytokine-chemokine network driven metastasis in esophageal cancer; promising avenue for targeted therapy.

ABSTRACT: Esophageal cancer (EC) is a disease often marked by aggressive growth and poor prognosis. Lack of targeted therapies, resistance to chemoradiation therapy, and distant metastases among patients with advanced disease account for the high mortality rate. The tumor microenvironment (TME) contains several cell types, including fibroblasts, immune cells, adipocytes, stromal proteins, and growth factors, which play a significant role in supporting the growth and aggressive behavior of cancer cells. The complex and dynamic interactions of the secreted cytokines, chemokines, growth factors, and their receptors mediate chronic inflammation and immunosuppressive TME favoring tumor progression, metastasis, and decreased response to therapy. The molecular changes in the TME are used as biological mark

SUBMITTER: Bhat AA 

PROVIDER: S-EPMC7780621 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature