CircNOL10 suppresses breast cancer progression by sponging miR-767-5p to regulate SOCS2/JAK/STAT signaling.

ABSTRACT:

Background

Circular RNAs (circRNAs) have caught increasing attentions and interests for their important involvement in cancer initiation and progression. This study aims to investigate the biological functions of circNOL10 and its potential molecular mechanisms in breast cancer (BC).

Materials and methods

qRT-PCR and western blot assays were performed to measure the expression of related genes. CCK-8, colony formation, flow cytomerty and transwell assays were used to assess cell proliferation, cell cycle, migration and invasion. RNA pull-down, luciferase reporter and RIP assays were applied to address the potential regulatory mechanism of circNOL10.

Results

CircNOL10 was down-regulated in BC tissues and cells. Low expression of circNOL10 was associated with larger tum

SUBMITTER: Wang F 

PROVIDER: S-EPMC7780627 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature