Neonatal Antiepileptic Medication Treatment Patterns: A Decade of Change.

ABSTRACT:

Objective

This study aims to describe the frequency and characteristics of anticonvulsant medication treatments initiated in the neonatal period.

Study design

We analyzed a cohort of neonates with a seizure diagnosis who were discharged from institutions in the Pediatric Health Information System between 2007 and 2016. Adjusted risk ratios and 95% confidence intervals for characteristics associated with neonatal (≤ 28 days postnatal) anticonvulsant initiation were calculated via modified Poisson regression.

Results

A total of 6,245 infants from 47 institutions were included. There was a decrease in both phenobarbital initiation within the neonatal period (96.9 to 91.3%, p = 0.015) and continuation at discharge (90.6 to 68.6%, p <0.001). Levetiracetam (7.

SUBMITTER: Le VT 

PROVIDER: S-EPMC7780727 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature