Sleep quality and prostate cancer aggressiveness: Results from the REDUCE trial.

ABSTRACT:

Background

Disrupted sleep has been associated with increased risk of certain cancers. Little data exist in prostate cancer. We tested the association between sleep quality and prostate cancer diagnosis overall and by tumor grade in the Reduction by Dutasteride of Prostate Cancer Events chemoprevention trial. We hypothesized that worse sleep quality would be associated with increased tumor aggressiveness.

Methods

At baseline, 5614 men completed a validated six-item questionnaire on sleep quality. We generated a composite score categorized into tertiles to measure overall sleep quality and assessed each sleep quality question individually. Logistic regression was used to test associations between baseline sleep quality and overall, low-grade and high-grade prostate cancer dia

SUBMITTER: Wiggins EK 

PROVIDER: S-EPMC7780858 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature