Periovulatory insulin signaling is essential for ovulation, granulosa cell differentiation, and female fertility.

ABSTRACT: Recent studies have demonstrated an essential role for insulin signaling in folliculogenesis as conditional ablation of Igf1r in primary follicles elicits defective follicle-stimulating hormone responsiveness blocking development at the preantral stage. Thus the potential role of insulin action in the periovulatory window and in the corpus luteum is unknown. To examine this, we generated conditional Insr,Igf1r, and double receptor knockout mice driven by Pgr-Cre. These models escape the preantral follicle block and in response to superovulatory gonadotropins exhibit normal distribution of ovarian follicles and corpora lutea. However, single ablation of Igf1r leads to subfertility and mice lacking both receptors are infertile. Double knockout mice have impaired oocyte development and ovulat

SUBMITTER: Sekulovski N 

PROVIDER: S-EPMC7781071 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature