Ketamine Alters Electrophysiological Responses to Emotional Faces in Major Depressive Disorder.

ABSTRACT:

Background

The glutamatergic modulator ketamine rapidly reduces depressive symptoms in individuals with treatment-resistant major depressive disorder (MDD). However, ketamine's effects on emotional processing biases remain largely unknown, and understanding these processes may help elucidate ketamine's mechanism of action.

Methods

Magnetoencephalography (MEG) was used to investigate ketamine's effects on early visual responses to affective stimuli in individuals with MDD (n=31) and healthy volunteers (HVs; n=24). Participants were enrolled in a double-blind, placebo-controlled, crossover clinical trial and were assessed at baseline and after subanesthetic-dose ketamine and placebo-saline infusions. During MEG recording, participants completed an emotional evaluation task in

SUBMITTER: Lundin NB 

PROVIDER: S-EPMC7781110 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature