Dynamic state with covarying brain activity-connectivity: On the pathophysiology of schizophrenia.

ABSTRACT: The human brain is a dynamic system that incorporates the evolution of local activities and the reconfiguration of brain interactions. Reoccurring brain patterns, regarded as "brain states", have revealed new insights into the pathophysiology of brain disorders, particularly schizophrenia. However, previous studies only focus on the dynamics of either brain activity or connectivity, ignoring the temporal co-evolution between them. In this work, we propose to capture dynamic brain states with covarying activity-connectivity and probe schizophrenia-related brain abnormalities. We find that the state-based activity and connectivity show high correspondence, where strong and antagonistic connectivity is accompanied with strong low-frequency fluctuations across the whole brain while weak and sp

SUBMITTER: Fu Z 

PROVIDER: S-EPMC7781150 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature