In Silico Identification of Chemicals Capable of Binding to the Ecdysone Receptor.

ABSTRACT: The process of molting, known alternatively as ecdysis, is a feature integral in the life cycles of species across the arthropod phylum. Regulation occurs as a function of the interaction of ecdysteroid hormones with the arthropod nuclear ecdysone receptor-a process preceding the triggering of a series of downstream events constituting an endocrine signaling pathway highly conserved throughout environmentally prevalent insect, crustacean, and myriapod organisms. Inappropriate ecdysone receptor binding and activation forms the essential molecular initiating event within possible adverse outcome pathways relating abnormal molting to mortality in arthropods. Definition of the characteristics of chemicals liable to stimulate such activity has the potential to be of great utility in mitigation

SUBMITTER: Mellor CL 

PROVIDER: S-EPMC7781155 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature