SARS-CoV-2 RNAaemia predicts clinical deterioration and extrapulmonary complications from COVID-19.

ABSTRACT: The determinants of COVID-19 disease severity and extrapulmonary complications (EPCs) are poorly understood. We characterise the relationships between SARS-CoV-2 RNAaemia and disease severity, clinical deterioration, and specific EPCs. We used quantitative (qPCR) and digital (dPCR) PCR to quantify SARS-CoV-2 RNA from nasopharyngeal swabs and plasma in 191 patients presenting to the Emergency Department (ED) with COVID-19. We recorded patient symptoms, laboratory markers, and clinical outcomes, with a focus on oxygen requirements over time. We collected longitudinal plasma samples from a subset of patients. We characterised the role of RNAaemia in predicting clinical severity and EPCs using elastic net regression. 23·0% (44/191) of SARS-CoV-2 positive patients had viral RNA detected in plas

SUBMITTER: Ram-Mohan N 

PROVIDER: S-EPMC7781329 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature