Hello, kitty: could cat allergy be a form of intoxication?

ABSTRACT:

Background

The relationship between slow loris (Nycticebus spp.) venom (BGE protein) and the major cat allergen (Fel d 1) from domestic cat (Felis catus) is known for about two decades. Along this time, evidence was accumulated regarding convergences between them, including their almost identical mode of action.

Methods

Large-scale database mining for Fel d 1 and BGE proteins in Felidae and Nycticebus spp., alignment, phylogeny proposition and molecular modelling, associated with directed literature review were assessed.

Results

Fel d 1 sequences for 28 non-domestic felids were identified, along with two additional loris BGE protein sequences. Dimer interfaces are less conserved among sequences, and the chain 1 shows more sequence similarity than

SUBMITTER: Ligabue-Braun R 

PROVIDER: S-EPMC7781471 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature