Metagenomics reveals impact of geography and acute diarrheal disease on the Central Indian human gut microbiome.

ABSTRACT:

Background

The Central Indian gut microbiome remains grossly understudied. Herein, we sought to investigate the burden of antimicrobial resistance and diarrheal diseases, particularly Clostridioides difficile, in rural-agricultural and urban populations in Central India, where there is widespread unregulated antibiotic use. We utilized shotgun metagenomics to comprehensively characterize the bacterial and viral fractions of the gut microbiome and their encoded functions in 105 participants.

Results

We observed distinct rural-urban differences in bacterial and viral populations, with geography exhibiting a greater influence than diarrheal status. Clostridioides difficile disease was more commonly observed in urban subjects, and their microbiomes were enriched in

SUBMITTER: Monaghan TM 

PROVIDER: S-EPMC7781581 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature