Damage to the structural connectome reflected in resting-state fMRI functional connectivity.

ABSTRACT: The relationship between structural and functional connectivity has been mostly examined in intact brains. Fewer studies have examined how differences in structure as a result of injury alters function. In this study we analyzed the relationship of structure to function across patients with stroke among whom infarcts caused heterogenous structural damage. We estimated relationships between distinct brain regions of interest (ROIs) from functional MRI in two pipelines. In one analysis pipeline, we measured functional connectivity by using correlation and partial correlation between 114 cortical ROIs. We found fMRI-BOLD partial correlation was altered at more edges as a function of the structural connectome (SC) damage, relative to the correlation. In a second analysis pipeline, we limited o

SUBMITTER: Wodeyar A 

PROVIDER: S-EPMC7781612 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature