Stabilization of negative activation voltages of Cav1.3 L-Type Ca²⁺-channels by alternative splicing.

ABSTRACT: -->Low voltage-activated Cav1.3 L-type Ca²⁺-channels are key regulators of neuronal excitability controlling neuronal development and different types of learning and memory. Their physiological functions are enabled by their negative activation voltage-range, which allows Cav1.3 to be active at subthreshold voltages. Alternative splicing in the C-terminus of their pore-forming α1-subunits gives rise to C-terminal long (Cav1.3_L) and short (Cav1.3_S) splice variants allowing Cav1.3_S to activate at even more negative voltages than Cav1.3_L. We discovered that inclusion of exons 8b, 11, and 32 in Cav1.3_S further shifts activation (-3 to -4 mV) and inactivation (-4 to -6 mV) to more negative voltages as revealed by functional chara

SUBMITTER: Hofer NT 

PROVIDER: S-EPMC7781618 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature