The gut bacterium Extibacter muris produces secondary bile acids and influences liver physiology in gnotobiotic mice.

ABSTRACT: Extibacter muris is a newly described mouse gut bacterium which metabolizes cholic acid (CA) to deoxycholic acid (DCA) via 7α-dehydroxylation. Although bile acids influence metabolic and inflammatory responses, few in vivo models exist for studying their metabolism and impact on the host. Mice were colonized from birth with the simplified community Oligo-MM¹² with or without E. muris. As the metabolism of bile acids is known to affect lipid homeostasis, mice were fed either a low- or high-fat diet for eight weeks before sampling and analyses targeting the gut and liver. Multiple Oligo-MM¹² strains were capable of deconjugating primary bile acids in vitro. E. muris produced DCA from CA either as pure compound or in mouse bile. This productio

SUBMITTER: Streidl T 

PROVIDER: S-EPMC7781625 | biostudies-literature | 2021 Jan-Dec

REPOSITORIES: biostudies-literature