Connective Tissue Growth Factor in Digestive System Cancers: A Review and Meta-Analysis.

ABSTRACT:

Aim

A meta-analysis was conducted to estimate the impact of connective tissue growth factor (CTGF) on outcomes in patients with digestive system cancers.

Methods

A systemic literature survey was performed by searching the Cochrane Library and PubMed databases for articles that evaluated the impact of CTGF on outcomes in patients with digestive system cancers. Hazard ratios and 95% confidence intervals were calculated for prognostic factors, overall and recurrence-free survival using RevMan 5.3 software.

Results

This meta-analysis was conducted to evaluate a total of 11 studies that included 1730 patients. The results showed that elevated CTGF expression was significantly correlated with advanced age, larger tumor size, multiple tumors, and vascular invasion. Subgroup

SUBMITTER: Zhao F 

PROVIDER: S-EPMC7781715 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature