Clinical Significance of CLDN18.2 Expression in Metastatic Diffuse-Type Gastric Cancer.

ABSTRACT:

Purpose

Isoform 2 of tight junction protein claudin-18 (CLDN18.2) is a potential target for gastric cancer treatment. A treatment targeting CLDN18.2 has shown promising results in gastric cancer. We investigated the clinical significance of CLDN18.2 and other cell-adherens junction molecules (Rho GTPase-activating protein [RhoGAP] and E-cadherin) in metastatic diffuse-type gastric cancer (mDGC).

Materials and methods

We evaluated CLDN18.2, RhoGAP, and E-cadherin expression using two-plex immunofluorescence and quantitative data analysis of H-scores of 77 consecutive mDGC patients who received first-line platinum-based chemotherapy between March 2015 and February 2017.

Results

CLDN18.2 and E-cadherin expression was significantly lower in patients with peritoneal metast

SUBMITTER: Kim SR 

PROVIDER: S-EPMC7781747 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature