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Immunotherapy with NK cells: recent developments in gene modification open up new avenues.

ABSTRACT: Chimeric antigen receptor (CAR)-T cell therapies have achieved remarkable success. However, application-related toxicities, such as cytokine release syndrome or neurotoxicity, moved natural killer (NK) cells into focus as novel players in immunotherapy. CAR-NK cells provide an advantageous dual killing-capacity by CAR-dependent and -independent mechanisms and induce few side effects. While the majority of trials still use CAR-T cells, CAR-NK cell trials are on the rise with 19 ongoing studies worldwide. This review illuminates the current state of research and clinical application of CAR-NK cells, as well as future developmental potential.

SUBMITTER: Reindl LM

PROVIDER: S-EPMC7781759 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature

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Immunotherapy with NK cells: recent developments in gene modification open up new avenues.

Reindl Lisa Marie LM Albinger Nawid N Bexte Tobias T Müller Stephan S Hartmann Jessica J Ullrich Evelyn E

Oncoimmunology 20200902 1

Chimeric antigen receptor (CAR)-T cell therapies have achieved remarkable success. However, application-related toxicities, such as cytokine release syndrome or neurotoxicity, moved natural killer (NK) cells into focus as novel players in immunotherapy. CAR-NK cells provide an advantageous dual killing-capacity by CAR-dependent and -independent mechanisms and induce few side effects. While the majority of trials still use CAR-T cells, CAR-NK cell trials are on the rise with 19 ongoing studies wo ...[more]

PMID: 33457093

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