Coagulation factor V is a marker of tumor-infiltrating immune cells in breast cancer.

ABSTRACT:

Background

Factor (F) V is an essential cofactor in blood coagulation, however, F5 expression in breast tumors has also been linked to tumor aggressiveness and overall survival. The specific role of FV in breast cancer is yet unknown. We therefore aimed at dissecting the biological relevance of FV in breast cancer.

Methods

Gene expression data from a Scandinavian breast cancer cohort (n = 363) and the cancer genome atlas (TCGA) (n = 981) and 12 replication cohorts were used to search for F5 co-expressed genes, followed by gene ontology analysis. Pathological and bioinformatic tools were used to evaluate immune cell infiltration and tumor purity. T cell activation, proliferation and migration were studied in FV treated Jurkat T cells.

Results

F5 co

SUBMITTER: Tinholt M 

PROVIDER: S-EPMC7781787 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature