Ontology highlight
ABSTRACT:
SUBMITTER: Reina-Ortiz C
PROVIDER: S-EPMC7781838 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Reina-Ortiz Chantal C Constantinides Michael M Fayd-Herbe-de-Maudave Alexis A Présumey Jessy J Hernandez Javier J Cartron Guillaume G Giraldos David D Díez Rosana R Izquierdo Isabel I Azaceta Gemma G Palomera Luis L Marzo Isabel I Naval Javier J Anel Alberto A Villalba Martín M
Oncoimmunology 20201229 1
In this study we evaluated the potential of expanded NK cells (eNKs) from two sources combined with the mAbs daratumumab and pembrolizumab to target primary multiple myeloma (MM) cells <i>ex vivo</i>. In order to ascertain the best source of NK cells, we expanded and activated NK cells from peripheral blood (PB) of healthy adult donors and from umbilical cord blood (UCB). The resulting expanded NK (eNK) cells express CD16, necessary for carrying out antibody-dependent cellular cytotoxicity (ADCC ...[more]