Nontumoral Portal Vein Thrombosis: A Challenging Consequence of Liver Cirrhosis.

ABSTRACT: Nontumoral portal vein thrombosis (PVT) is an increasingly recognized complication in patients with cirrhosis. Substantial evidence shows that portal flow stasis, complex thrombophilic disorders, and exogenous factors leading to endothelial dysfunction have emerged as key factors in the pathogenesis of PVT. The contribution of PVT to hepatic decompensation and mortality in cirrhosis is debatable; however, the presence of an advanced PVT increases operative complexity and decreases survival after transplantation. The therapeutic decision for PVT is often determined by the duration and extent of thrombosis, the presence of symptoms, and liver transplant eligibility. Evidence from several cohorts has demonstrated that anticoagulation treatment with vitamin K antagonist or low molecular weight

SUBMITTER: Rugivarodom M 

PROVIDER: S-EPMC7782107 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature