Comparison of fibrin sealants in peripheral vascular surgery: A systematic review and network meta-analysis.

ABSTRACT:

Background

Evidence comparing fibrin sealants (FSs) in surgery are limited. This study evaluated the efficacy and safety of FSs, and manual compression in peripheral vascular surgery.

Methods

A systematic review of randomized trials was conducted in Medline, Embase, and Cochrane databases within the last 15 years. Data were available to conduct a network meta-analysis (NMA) in peripheral vascular surgery. Fibrin sealant treatment arms were further broken-down and assessed by clotting time (i.e., 2-min [2C] or 1-min [1C]). The primary efficacy outcome was the proportion of patients achieving hemostasis by 4 min (T4). Treatment-related serious and non-serious adverse events (AEs) were qualitatively assessed.

Results

Five studies (n = 693), were included in the NMA. Resu

SUBMITTER: Danker Iii W 

PROVIDER: S-EPMC7782199 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature