Fatal Rhinofacial Mycosis Due to Aspergillus nomiae: Case Report and Review of Published Literature.

ABSTRACT:

Background

A 73-year-old female suffering from acute myeloid leukemia presented with progressive rhinofacial mycosis. Suspecting it to be mucormycosis, the antifungal amphotericin B (AMB) was administered empirically, but the patient did not respond as planned. The fungus was then isolated from the biopsied tissue and morphologically identified as a species of Aspergillus. Necrosis progressed and she died of cerebral hemorrhage. Since Aspergillus flavus is susceptible to AMB, and several other Aspergillus species can be misidentified as A. flavus, the observed resistance necessitated a re-examination of the fungal isolate.

Methods

The fungal strain was re-isolated and re-examined morphologically. Additionally, genomic DNA was extracted from the fu

SUBMITTER: Zhou YB 

PROVIDER: S-EPMC7782315 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature