TLR agonists enhance responsiveness of inflammatory innate immune cells in HLA-B*57-positive HIV patients.

ABSTRACT: HLA-B*57 affects the course of HIV infection. Under antiretroviral therapy, its effects cannot be explained by outstandingly efficient T cell responses alone but may also involve cells of innate immunity. Studying in vitro stimulation with Pam3CSK4, E. coli LPS-B5 and CpG-ODN-2216, we observed greater induction of IL-6/IL-1beta double-positive CD14⁺CD16⁺⁺ monocytes as well as IFN-gamma-positive cytotoxic CD56^highCD16^neg NK cells in HLA-B*57- versus HLA-B*44-positive HIV patients, while TNF-alpha induction remained unchanged. Differences were not seen in the other monocyte and NK cell subsets or in HLA-matched healthy controls. Our findings show that, in virally suppressed HIV infection, HLA-B*57 is associated with enhanced responsiveness of infla

SUBMITTER: Dold L 

PROVIDER: S-EPMC7782382 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature