Clinicopathological and prognostic significance of PD-L1 expression in colorectal cancer: a meta-analysis.

ABSTRACT:

Purpose

To systematically evaluate the correlation between PD-L1 expression and clinicopathological features and prognosis of colorectal cancer (CRC).

Methods

Seven databases (PubMed, Cochrane Library, EMBASE, Web of Science, CBM, Wanfang, and CNKI) were searched through May 2020. Risk of bias and quality of evidence were assessed by using the Newcastle-Ottawa scale (NOS), and meta-analysis was carried out by using the Review Manager 5.3 software on the studies with the quality evaluation scores ≥ 6. Meta-regression analysis was used to determine the independent role of PD-L1 expression on CRC prognosis after adjusting clinicopathological features and treatment methods.

Results

A total of 8823 CRC patients in 32 eligible studies. PD-L1 expression was correlated with l

SUBMITTER: Wang S 

PROVIDER: S-EPMC7782388 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature