Longitudinal PET Imaging to Monitor Treatment Efficacy by Liposomal Irinotecan in Orthotopic Patient-Derived Pancreatic Tumor Models of High and Low Hypoxia.

ABSTRACT:

Purpose

Hypoxia is linked to aggressiveness, resistance to therapy, and poor prognosis of pancreatic tumors. Liposomal irinotecan (nal-IRI, ONIVYDE®) has shown potential in reducing hypoxia in the HT29 colorectal cancer model, and here, we investigate its therapeutic activity and ability to modulate hypoxia in patient-derived orthotopic tumor models of pancreatic cancer.

Procedures

Mice were randomized into nal-IRI treated and untreated controls. Magnetic resonance imaging was used for monitoring treatment efficacy, positron emission tomography (PET) imaging with F-18-labelled fluoroazomycinarabinoside ([¹⁸F]FAZA) for tumor hypoxia quantification, and F-18-labelled fluorothymidine ([¹⁸F]FLT) for tumor cell proliferation.

Results

The highly hypoxi

SUBMITTER: Ventura M 

PROVIDER: S-EPMC7782415 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature