Response to neoadjuvant treatment among rectal cancer patients in a population-based cohort.

ABSTRACT:

Background

In rectal cancer, prediction of tumor response and pathological complete response (pCR) to neoadjuvant treatment could contribute to refine selection of patients who might benefit from a delayed- or no-surgery approach. The aim of this study was to explore the association of clinical and molecular characteristics of rectal cancer with response to neoadjuvant treatment and to compare patient survival according to level of response.

Methods

Resected rectal cancer patients were selected from a population-based cohort study. Molecular tumor markers were determined from the surgical specimen. Tumor response and pCR were defined as downstaging in T or N stage and absence of tumor cells upon pathological examination, respectively. The associations of patient and tumor ch

SUBMITTER: Alwers E 

PROVIDER: S-EPMC7782441 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature