Neurofilament light as an outcome predictor after cardiac arrest: a post hoc analysis of the COMACARE trial.

ABSTRACT:

Purpose

Neurofilament light (NfL) is a biomarker reflecting neurodegeneration and acute neuronal injury, and an increase is found following hypoxic brain damage. We assessed the ability of plasma NfL to predict outcome in comatose patients after out-of-hospital cardiac arrest (OHCA). We also compared plasma NfL concentrations between patients treated with two different targets of arterial carbon dioxide tension (PaCO₂), arterial oxygen tension (PaO₂), and mean arterial pressure (MAP).

Methods

We measured NfL concentrations in plasma obtained at intensive care unit admission and at 24, 48, and 72 h after OHCA. We assessed neurological outcome at 6 months and defined a good outcome as Cerebral Performance Category (CPC) 1-2 and poor outcome as CPC 3-5.

SUBMITTER: Wihersaari L 

PROVIDER: S-EPMC7782453 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature